A Kikuchi-Fujimoto Disease Case Mimicking T Cell Lymphoma with Prolonged Fever

Kikuchi-Fujimoto disease (KFD) is a self-limited disease characterized by necrotizing lymphadenitis. Although cervical lymphadenitis in young women is the most familiar clinical presentation, it may take place in the etiology of fever in cases presenting with fever of unknown origin. A 33-year-old male case admitted with fever, nausea, vomiting, weight loss, and leukopenia for one month, subsequently developing axillary lymphadenopathy during followup, diagnosed as KFD with typical histopathological findings, and showing full recovery after the excision of lymph node was presented in this report

Ekmeklik Buğdayda Genotip, Ekim Zamanı ve Tohum Fungusiti Ön Uygulamalarının Kök ve Kök Boğazı Çürüklüğü ve Tane Verimi Üzerine Etkileri

This study was carried out to investigate the effects of sowing time,cultivar and seed fungicide applications on root and crown rot diseaseand grain yield of bread wheat with different earliness traits (Esperia,mid-early; Genesi, late and Anapo, early) in the experiment station ofthe Department of Field Crops, Faculty of Agriculture, TekirdağNamık Kemal University. Four different fungicides pre-treatments(prothioconazole + tebuconazole, carboxin + thiram, prochloraz +tiriticonazole and control) were applied to the seeds of the varietiesbefore sowing in three different times, on 1 November, 15 Novemberand 30 November 2016. The experiment was designed as a split-splitplot with 3 replications. The results of the variance analysis showedthat the effect of applying different seed fungicide pre-treatment rootand crown rot of bread wheat varieties was statistically significant.While the lowest root and crown rot with 2.67 % was obtained fromthe second sowing time, the highest root and crown rot wasdetermined with a value of 3.64% for the earliest sowing on 01November. Among the four different fungicide pre-treatments, thehighest root and crown rot (5.59%) was obtained in the controlapplication, while the lowest root and crown rot was obtained inprothioconazole + tebuconazole, carboxin + thiram and prochloraz +triticonazole, with 1.96%, 2.10% and 2.19% root and crown rot,respectively. These data indicate that early sowing may increase rootand crown rot severity.Bu çalışma, Tekirdağ Namık Kemal Üniversitesi Ziraat Fakültesi Tarla Bitkileri Bölümü deneme alanında ekim zamanı, çeşit ve tohum ilacı uygulamalarının buğdayda kök ve kök boğazı çürüklüğü hastalıkları ile buğday dane verimine etkilerini araştırmak amacıyla yürütülmüştür. Araştırmada vejetasyon süreleri farklı olan 3 adet ekmeklik buğday çeşidi (Esperia:orta erkenci, Genesi: geççi ve Anapo: erkenci) kullanılmıştır. Ekimden önce bu çeşitlerin tohumlarına dört farklı fungisit (prothioconazole + tebuconazole, karboxin + thiram, prochloraz + tiriticonazole ve kontrol) uygulanarak 1 Kasım, 15 Kasım ve 30 Kasım 2016 olmak üzere 3 farklı zamanda ekimler yapılmıştır. Deneme, Tekirdağ Namık Kemal Üniversitesi Ziraat Fakültesi Tarla Bitkileri Bölümü deneme alanlarında, bölünen bölünmüş parseller deneme desenine göre 3 tekrarlamalı olarak düzenlenmiştir. Çalışmada, varyans analizi sonuçlarına göre farklı tohum fungusiti uygulamalarının ekmeklik buğday çeşitlerinin kök ve kök çürüklüğü üzerine etkisi istatistiki olarak önemli bulunmuştur. Farklı ekim zamanlarında en düşü kök ve kök boğazı çürüklüğü %2.67 ile ikinci ekim zamanında elde edilirken, en yüksek kök ve kök boğazı çürüklüğü %3.64 ile en erken ekim olan 01 Kasım ekiminde belirlenmiştir. Dört farklı tohum fungusit uygulamasında en yüksek kök boğazı çürüklüğü (%5.59) kontrol uygulamasından elde edilirken, en düşük kök boğazı çürüklüğü %1.96, %2.10 ve %2.19 ile sırasıyla aynı istatistiki grupta yer alan prothioconazole + tebuconazole, karboxin + thiram ve prochloraz + triticonazole ön uygulamalarından elde edilmiştir. Elde edilen veriler, erken ekim zamanının kök ve kök boğazı çürüklüğünün şiddetini arttırdığını göstermektedir. Y 1https://orcid.org/ 2https://orcid.org/, 3https://orcid.org

The Effect of Grazing Applied in the Different Phenological Stages on Yield and Yield Components of Bread Wheat and Triticale

Bu çalışma, Namık Kemal Üniversitesi, Ziraat Fakültesi, Tarla Bitkileri Bölümü uygulama arazisinde iki yıl (2003-04 and 2004-05) süreyle yürütülmüştür. Araştırmada, iki ekmeklik buğday ve iki tritikale çeşidinin verim ve verim unsurları üzerine, farklı fenolojik dönemlerde yapılan otlatma uygulamalarının (a- otlatılmamış (kontrol), b- bir defa otlatılmış (fide döneminde), c- iki defa otlatılmış (fide dönemi+kardeşlenme dönemi), d- üç defa otlatılmış (fide dönemi+kardeşlenme dönemi+sapa kalkma dönemi)) etkisi incelenmiştir. Denemeler, tesadüf bloklarında bölünmüş parseller deneme deseninde çeşitler ana parselleri, otlatma uygulamaları alt parselleri oluşturacak şekilde kurulmuştur. Otlatma uygulamaları çim biçme makinesiyle simulize edilmiştir. Araştırmadan elde edilen sonuçlara göre; otlatma, araştırmada kullanılan tahıl türlerinin tane verimi ve verim komponentlerini olumsuz yönde etkilemiştir. Tane verimindeki ortalama azalma, bir defa otlatma yapıldığında % 8.43, iki defa otlatma yapıldığında % 16.47 ve üç defa otlatma yapıldığında % 52.57 düzeyinde olmuştur. Tane veriminde meydana gelen azalmalar yıla, türlere, çeşide ve tane hasadından önceki gelişme için kalan süreye bağlı olarak değişmiştir. Tekirdağ koşullarında yürütülen bu çalışmanın sonuçları, bölgede kaba yem açığının olduğu yıllarda ekimden yaklaşık en az 12 hafta sonra erken bahar aylarında ekmeklik buğday ve tritikalenin tane veriminde önemli düşüşlere sebebiyet vermeden bir kez otlatılabileceğini göstermektedir.This study was conducted during two growing seasons, 2003-04 and 2004-05, at experimental farm of Field Crops Department of Agricultural Faculty of Namik Kemal University of Turkey. In the study, the effects of grazing regimes (a. control, b. 1 time grazing. c. 2 times grazing and d. 3 times grazing) on grain yield and related characteristics of 2 bread wheat and 2 triticale cultivars were investigated. The experimental design was split plot on randomized blocks, with cultivars as the main plot and grazing regimes as subplot. Grazing was simulated by lawn cutter. According to the results of the study, grazing regimes significantly reduced grain yield and related characteristics. The average reduction in grain yield was 8.43% in only one time grazed, 16.47 % in 2 times grazed and 52.57% in 3 times grazed plots. The reduction in grain yield varied according to year, species, cultivars and grazing date. The results of the study indicate that approximately 12 weeks after sowing, bread wheat and triticale can be grazed one time in the years when there is a shortage of forage

İnfektif endokarditin epidemiyolojik, klinik ve prognostik sonuçları: 90 atağın retrospektif kohortu

To evaluate the epidemiological, clinical, microbiological, and echocardiographic features, as well as the prognosis and long- term outcome of patients with infective endocarditis. Methods: The clinical records and follow-up data of 90 endocarditis episodes in 86 patients diagnosed with definite and possible infec- tive endocarditis according to the modified Duke criteria in a tertiary university hospital, between 1998 and 2016, were reviewed. Results: Fifty-six patients were male (65.1%), and the mean age was 49.9 ± 14.3. Native valve endocarditis constituted 62.2% of the cases, while the remaining patients had prosthetic valve endocarditis. The aortic (34.4%) and mitral (24.4%) valves were infected more frequently. Streptococci (27.7%) and staphylococci (24.4%) were the most frequently isolated microorganisms. Embolic complications (35.5%) were the leading cause of morbidity, followed by valve insufficiency (28.8%) and heart failure (21.1%). Valve replacement surgery was performed in 28 patients (31%). The in-hospital mortality rate was 15.1% (n = 13). Chronic renal failure (P = .042) and degenerative valves (P = .036) were significantly associated with mortality. Among 43 of the 73 cases available for telephonic survey, 36 (83.7%) patients were alive and without disease, with a median follow-up of 52.9 (4-163) months. Twenty-five (69.4%) of these patients were younger than 55 years, and 24 (66.6%) had native valve endocarditis. Conclusion: Underlying cardiac conditions and chronic renal failure increase mortality in infective endocarditis, regardless of the patho- gen. Long-term survival seems promising in cases with native valve endocarditis and in younger patients with low rates of comorbidities.İnfektif endokardit tanısıyla izlenen hastaların epidemiyolojik, klinik, mikrobiyolojik, ekokardiyografik özellikleri, prognozu ve uzun dönem sonuçlarını değerlendirmek. Yöntemler: 1998 ve 2016 yılları arasında bir üniversite hastanesinde modifiye Duke kriterlerine göre kesin ve olası infektif endokardit tanısı konan 86 hastanın 90 endokardit atağının klinik kayıtları ve takip verileri retrospektif olarak incelendi. Bulgular: Çalışmamızda hastaların 56’sı (%65,1) erkek ve ortalama yaş 49,9 ± 14,3 idi. Doğal kapak endokarditi olguların %62,2’sini oluştururken, diğerlerinde protez kapak mevcuttu. En sık aort (%34,4) ve mitral (% 24,4) kapak tutulumu saptandı. Etken olarak strep- tokoklar (%27,7) ve stafilokoklar (%24,4) en sık izole edilen mikroorganizmalardı. Tüm komplikasyonlar içinde embolik komplikasyonlar (%35,5) ilk sırada yer almış, bunu kapak yetmezlikleri (%28,8) ve kalp yetmezliği (%21,1) izlemiştir. Hastaların 28’ine (%31) kapak replasman operasyonu yapılmış ve tüm hastalar içinde 13 hasta (%15,1) hastane takibinde kaybedilmiştir. Mortalite kronik böbrek yetmezliği (P = ,042) ve dejeneratif kapak hastalarında (P = ,036) istatistiksel olarak daha anlamlı bulundu. Taburculuk sonrası prognoz ve uzun dönem sonuçlar değerlendirildiğinde sağ kalan 73 hastanın 43’üne ulaşılabilmiş ve bu hastalardan 36’sının (%83,7) ortalama 52,9 ay (4-163) hayatta ve genel durumlarının iyi olduğu, 25 hastanın (%69,4) <55 yaş, 24’ünün (%66,6) doğal kapak endokarditi tanısıyla izlenmiş olduğu görülmüştür. Sonuç: İnfektif endokardit hastalarında altta yatan kalp hastalıkları ve kronik böbrek yetmezliği patojenden bağımsız olarak mortalit- eyi arttırmaktadır. Doğal kapak endokarditi ve komorbiditeleri daha az olan genç yaş hastalarda ise uzun dönem sağkalım umut verici görünmektedir

Heterologous booster COVID-19 vaccination elicited potent immune responses in HCWs

The objective of our study was to evaluate the antibody responses of health care workers (HCWs) who were vaccinated with booster dose BNT162b2 6 months after 2 doses of the CoronoVac vaccine. The study included 318 HCWs vaccinated with inactive CoronaVac SARS-CoV-2 vaccine in 2 doses. Anti-spike/RBD IgG levels were measured immediately before and 1 month after the booster dose. In the sixth month after CoronaVac vaccination, the median of antibody levels of 1212.02 AU/ML, while it was 9283 AU/mL after BNT162b2 vaccination. IgG antibody titers of over 1050 AU/mL (which is equivalent to 1:80 dilution in the plaque reduction neutralization test) were detected in HCWs 15.09% and 97.8%, respectively. Our results showed that antibody titers increased 8-fold after the booster dose. We believe that the administration of the mRNA vaccine as a booster dose can provide more effective protection against COVID-19 infection, especially in individuals with risk factors.IU-Cerrahpaşa Scientific Research Projects Uni

Waning immunity to inactive SARS-CoV-2 vaccine in healthcare workers: Booster required

Aims Despite high vaccination rates, increasing case numbers continue to be reported with the identification of new variants of concern, and the issue of durability of the vaccine-induced immune response remains hot topic. Real-life data regarding time-dependent immunogenicity of inactivated COVID-19 vaccines are scarce. We aimed to investigate the changes in the antibody at the different times after the second dose of the CoronaVac vaccine. Methods The study included 175 HCWs vaccinated with inactive CoronaVac (Sinovac Life Sciences, China) SARS-CoV-2 vaccine in two doses. Anti-spike/RBD IgG levels were measured first, third, and sixth months after the second dose. Chemiluminescent microparticle immunoassay (IgG II Quant test, Abbott, USA), which is 100% compatible with plaque reduction neutralization test, was used. Results Mean age of the participants was 38 +/- 11.23 years (range between 22 and 66) of whom 119 (63.9%) were female, and 56 (32%) were male. Dramatic reductions were demonstrated in median antibody levels particularly in the infection-naive group, comprising 138 HCWs compared to those with prior history of COVID-19 infection (n = 37) (p < 0.001). There was no difference between the two groups in terms of age, gender, blood groups, BMI, and comorbid diseases. Conclusions While antibody positivity remained above 90% in the 6th month after two doses of inactivated vaccine in HCWs, the median titers of neutralizing antibodies decreased rapidly. The decrease was more rapid and significant in those with no history of prior COVID-19 infection. In this critical phase of the pandemic, where we are facing the dominance of the Omicron variant after Delta, booster doses have become vital.IU-Cerrahpasa Scientific Research Projects Uni

Interview with Marjorie Harkins Buchanan Kiewit

In this interview with Julia Stringfellow, Marjorie Harkins Buchanan Kiewit, LU class of 1943, discusses her time as a student as well as her time on the Board of Trustees.https://lux.lawrence.edu/oralhistories/1036/thumbnail.jp

Real-world efficacy and safety of Ledipasvir plus Sofosbuvir and Ombitasvir/Paritaprevir/Ritonavir +/- Dasabuvir combination therapies for chronic hepatitis C: A Turkish experience

Background/Aims: This study aimed to evaluate the real-life efficacy and tolerability of direct-acting antiviral treatments for patients with chronic hepatitis C (CHC) with/without cirrhosis in the Turkish population.Material and Methods: A total of 4,352 patients with CHC from 36 different institutions in Turkey were enrolled. They received ledipasvir (LDV) and sofosbuvir (SOF)+/- ribavirin (RBV) ombitasvir/paritaprevir/ritonavir +/- dasabuvir (PrOD)+/- RBV for 12 or 24 weeks. Sustained virologic response (SVR) rates, factors affecting SVR, safety profile, and hepatocellular cancer (HCC) occurrence were analyzed.Results: SVR12 was achieved in 92.8% of the patients (4,040/4,352) according to intention-to-treat and in 98.3% of the patients (4,040/4,108) according to per-protocol analysis. The SVR12 rates were similar between the treatment regimens (97.2%-100%) and genotypes (95.6%-100%). Patients achieving SVR showed a significant decrease in the mean serum alanine transaminase (ALT) levels (50.90 +/- 54.60 U/L to 17.00 +/- 14.50 U/L) and model for end-stage liver disease (MELD) scores (7.51 +/- 4.54 to 7.32 +/- 3.40) (p<0.05). Of the patients, 2 were diagnosed with HCC during the treatment and 14 were diagnosed with HCC 37.0 +/- 16.0 weeks post-treatment. Higher initial MELD score (odds ratio [OR]: 1.92, 95% confidence interval [CI]: 1.22-2.38; p=0.023]), higher hepatitis C virus (HCV) RNA levels (OR: 1.44, 95% CI: 1.31-2.28; p=0.038), and higher serum ALT levels (OR: 1.38, 95% CI: 1.21-1.83; p=0.042) were associated with poor SVR12. The most common adverse events were fatigue (12.6%), pruritis (7.3%), increased serum ALT (4.7%) and bilirubin (3.8%) levels, and anemia (3.1%).Conclusion: LDV/SOF or PrOD +/- RBV were effective and tolerable treatments for patients with CHC and with or without advanced liver disease before and after liver transplantation. Although HCV eradication improves the liver function, there is a risk of developing HCC.Turkish Association for the Study of The Liver (TASL